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Cyclodextrin is a cyclic oligomer obtained by fermentation of glucose transferase. Because of its unique three-dimensional structure, the inclusion of guest molecules can be carried out, and it is widely used in various fields.
Cyclodextrins are widely believed to be non-toxic and excreted in the whole form after ingestion. They are not involved in the metabolism of the body. So how does it metabolize in the human body?
Cyclodextrin enters the human body in two ways: one is the gut, and the other two is the non gut. Metabolism of these two ways of cyclodextrin in the human body is not the same, the first way is oral, the study found that people with cyclodextrin gut decomposition in the colon, carbon dioxide and water discharge, the time for 4-8 hours after oral administration; second ways is the purpose of injection, cyclodextrin not absorbed by cells, the human circulatory system excreted through the kidney. These two methods fully reflect that cyclodextrins are relatively stable in the human body, and most of them are excreted in complete form without damaging the body.
As a green supramolecular matrix, cyclodextrins have become more and more active in the fields of food, pharmaceutical, agriculture, cosmetics, textiles, nano coatings, chemical analysis, molecular recognition and catalytic reactions.
Scientific Research Special Cyclodextrin Reagent mainly including Oligo Beta Cyclodextrin, Mono-6-Azido-6-Deoxy Beta Cyclodextrin, Mono Hexamethylenediamine Beta Cyclodextrin, Mono-6-Ethanediamine-6-Deoxy Beta Cyclodextrin, Mono-6-p-Toluenesulfonyl Beta Cyclodextrin, Polyethylene Polyamine Modified Beta Cyclodextri,mono azido beta cyclodextrin cas 98169-85-8,Oligo Beta Cyclodextrin cas 98169-85-8.
Oligo (lactic acid) -beta-cyclodextrin (OLA-B-CD) is a new cyclodextrin derivative. Oligo-(lactic acid) group that can be degraded in the human body modified cyclodextrin with the general characteristics of common cyclodextrin derivatives, also has unique properties: 1, excellent biocompatibility. 2, excellent controlled release of specific guest molecular. 3, adjustable water-solubility. 4, capability to form duel interactions with specific drugs [1].
OLA-β-CD can be used to improve the solubility of water insoluble drugs, enhance drug stability and bioavailability, and achieve controlled release system or delayed release system of drugs. OLA-β-CD is of immense value in the field of drug development.
Features and use of Mono-6-Ethanediamine-6-Deoxy Beta Cyclodextrin:
Organic amine groups in a neutral or acid conditions can be positively charged which have very good composite ability to guest molecules.
Diamine group can form complex with many metal ions , such as Cu2+,Cr3+,Mg2+ and so on. This provide new approachs to achieve artifical enzyme and highlight supramolecular researches.
Diamine also provide a secondary amine group and a primary amine group which can be linked to many functional group. This make diamine cyclodextrin an important intermediate for cyclodextrin synthsis.
Scientific Research Special Cyclodextrin Reagent
Mono Azido Deoxy Beta Cyclodextrin,Polyethylene Polyamine Modified Beta Cyclodextrin, Mono Toluenesulfonyl Beta Cyclodextrin, Mono Ethanediamine Deoxy Beta Cyclodextrin
Zhiyuan Biotchnology , http://www.zycydextrin.com